Anti Ageing Cream without Irritation

14 Day Irritation Guarantee | Free UK Shipping

14 Day No Irritation Guarantee

Retinoid Results Without

The Irritation

Experience gentle, yet powerful results proven to work — all with zero irritation.

Try Night Repair Therapy Now

A jar of The Skin Diary Night Repair Therapy cream with a black lid and a amber glass container, shown on a white background with a soft shadow.

A jar of The Skin Diary Night Repair Therapy cream shown on a dark brown background with text highlighting benefits over retinol and increased collagen.

Benefits graphic with text listing skin benefits: reduces fine lines and wrinkles, improves skin firmness and elasticity, improves skin tone and texture, and renews and strengthens skin barrier, over a lifestyle photo of a woman applying skincare in a bathroom.

A collage of The Skin Diary Night Repair Therapy cream arranged on a light beige background, with two jars open to show the white cream inside and two closed. The jars are a warm amber colour with black lids and white labels.

Close-up before-and-after comparison of an eye area showing skin texture and wrinkles, with 'BEFORE' on the top and 'AFTER 3 MONTHS' on the bottom.

Before-and-after comparison of a person's mouth area showing skin and lip texture after 3 months, with 'BEFORE' on the top and 'AFTER 3 MONTHS' on the bottom.

A close-up of a velvety white night repair therapy product swirled inside an amber jar.

A dark brown graphic communicating The Skin Diary 'Cell-to-Surface' standard. 'Tested at the Cell', 'Measured on the Surface', and 'Perceived in the Mirror'. The product was tested by all three tiers

A quote about collagen and elastic fibres from University of Manchester researcher Dr. Abigail Langton

Night Repair Therapy

Reverse signs of ageing using powerful, clinically proven skin repair — without irritation. If you want the results of retinol without the redness, Night Repair Therapy has been designed with you in mind. We believe optimal ageing doesn’t have to come with retinol uglies.

£135.00

20x more effective than retinol

Boosts collagen and elastin for firmer, youthful skin

Repairs sun damage (key driver of premature ageing) and restores skin barrier health

Developed by world-leading dermatologists

Gentle, irritation-free formula suitable for sensitive skin

Free Shipping | Irritation Guarantee

INGREDIENTS

IRRITATION GUARANTEE

Rigorously Tested. Proven Three Times

With double blind placebo skin biopsy studies, clinical trials, and consumer trials. Night Repair Therapy has been proven to deliver results both visually and on a cellular level resulting in healthier, more youthful-looking skin.

Increase in collagen & fibrillin in human skin biopsies^[1]

Proven to Reduce Wrinkles in 12 Weeks

Clincally proven to significantly reduce wrinkles in 12 weeks^[2]

93%

Reported healthier looking skin^[3]

[1] Langton AK, McConnell JC, Cotterell LF, Halai P, Griffiths TW, Griffiths CEM, Watson REB. Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse (Night Repair Therapy), a novel over-the-counter anti-ageing product. J Eur Acad Dermatol Venereol. 2022 Jan;36(1):e43-e46. doi: 10.1111/jdv.17612. Epub 2021 Aug 30. PMID: 34416056.

[2] Independent clinical trial of 29 participants over 12 weeks

[3] Independent consumer study of 44 participants over 12 weeks.

Test 1.

Manchester Patch Test Assay

Results

Test Type

Scientific Standard

Testing Process

Purpose of Test

Test 2. Clinical Trials

Results

Test Type

Scientific Standard

Testing Process

Purpose of Test

Test 3. Consumer Trials

Results

Test Type

Scientific Standard

Testing Process

Purpose of Test

The Pyramid of Final Formulation Testing

FOR COSMETIC SKINCARE

Quality of Evidence

1
Biopsy
Biomarkers
Randomised
Controlled CT

1. Biopsy-based Scientific biomarkers Randomised Controlled Clinical Trials:

A study where objective scientific skin biopsy and biomarker-based measurements are performed on a group of volunteers who have used the product (with active ingredients) for a period of time, and a comparison is made to a 'control' product (which is ideally the same except for the active components).

The Manchester Patch Test Assay falls into this category and is considered the gold standard of testing for cosmetic skincare products.

Learn more about The Manchester Patch Test Assay

2
Non-Invasive
Randomised
Controlled CT

2. Randomised Controlled Clinical Trials:

A study where objective scientific measurements of surface changes are performed on a group of volunteers who have used the product (with active ingredients) for a period of time, and a comparison is made to a 'control' product (which is ideally the same except for the active components)

3
Non-Invasive
Clinical Trials (CT)

3. Clinical Trials:

A study where objective scientific measurements of surface changes are performed on a panel of volunteers who have used the product for a period of time.

This is the most common trial used when a cosmetic brand says "Clinically proven to.."

4
Consumer Studies

4. Consumer Perception Studies:

A survey of a panel of volunteers who have used the product for a period of time to understand their experience of the product.

This test is useful to ensure a consumers experience matches more rigorous scientific measures. This is the most common study used when a brand says. "90% of people experienced..."

Click on a section to see the explanation of the test

Most cosmetics are tested on visible results only (3,and/or 4) Night Repair Therapy raises the bar in cosmetic testing by completing tests 1, 3, and 4 not only proving visible results, but results on a cellular level.

Night Repair Therapy’s Superior Results Without Irritation

Carefully selected ingredients that work synergistically together.

Protect

Preserving those healthy skin cells is key to minimise tissue degradation and prevent inflammation-induced ageing.

Repair

This is where the cellular science happens. The reparative ingredients get to work repairing collagen and elastic fibres to reveal a more youthful complexion.

Restore

Skin health first, always. We restore the skin barrier while the actives get to work. Without a strong, healthy skin barrier powerful ingredients can’t do their job. A happy skin barrier = no irritation.

Start Your Skin Health Journey Today