The Complete Skin Ageing Duo
The Complete Skin Ageing Duo
Daily protection against accelerated skin ageing in a beautifully formulated, deeply nourishing single step morning routine combined with our award-winning night cream - proven to be 20x more effective than retinol, without the Irritation.
- Skincare Simplified: A complete, high-performance daily routine in two elegant steps.
- 24-Hour Synergy: Protects your progress by day; supports deep structural renewal by night.
- Clinically Proven: Validated at the cellular level to protect collagen and visibly reduce wrinkles.
- Sensitive Skin Safe: Clinical-grade actives engineered to strengthen your barrier.
MULTI-AWARD WINNING RESULTS
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The Complete Skin Ageing Duo
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KEY BENEFITS
AM: Protects & Preserves
Age Defence is clinically proven to protect against daily collagen degradation, inflammation, and environmental stress. It locks in your nighttime results while providing invisible, encapsulated UV defence.[1]PM: Renews & Strengthens
Night Repair Therapy delivers advanced cellular support—up to 20x more effectively than standard retinol, without the visible irritation commonly associated with retinoids.[2]Supports Natural Recovery
Advanced daytime DNA repair enzymes meet nighttime cell-communicating peptides to foster continuous, 24-hour biological support.[3]Deep, 24/7 Hydration
Enjoy an invisible, velvet-matte finish under your morning makeup, and deeply nourishing, barrier-restoring moisture while you sleep.[4]View Citations
As Featured In
BEFOREAFTER
BEFOREAFTER
BEFOREAFTER
BEFOREAFTER
PURE SCIENCE. PROVEN RESULTS
Proven Results
Rigorously tested across all three dimensions of our Cell-to-Surface™ standard
BIOLOGICAL EFFICACY
*AM: In skin exposed to solar-simulated UV radiation, Age Defence reduced the expression of key biomarkers associated with collagen degradation, inflammation, compared to untreated UV-exposed controls. PM: Proven in independent Manchester Patch Test Assay at the university of Manchester
CLINICAL STUDY
* Proven in independent clinical trials
Consumer Validated
* Proven in independent consumer studies
Night Repair Therapy
1. Tested at the Cellular Level
The Manchester Patch Test Assay
The Process
Intra-subject controlled, double-blinded study on human volunteers with skin biopsies taken and biomarkers examined under microscope. Validated & bench-marked against prescription product.
The Purpose
Rapidly models 6 months of use on live human skin.
The Results
- Outperformed gold standard (equivalent 20x more effective than retinol).
- 2x increase in collagen.
- 2x increase in fibrillin.
2. Measured on the Surface
Clinical Trial
The Process
29 people have baseline professional Visioscan in controlled conditions to measure wrinkle depth, images are taken before using the product, at 7 days, 4 weeks and 12 weeks. Computer-measured wrinkles are compared to the baseline.
The Purpose
A good study to see if visual improvements are obtained from use of the product.
The Results
Significant reduction in wrinkles with statistical significance of p=0.0004 in as little as 7 days.
3. Perceived in the Mirror
Consumer Trial
The Process
44 people are provided with the product to use for 12 weeks, volunteers are asked questions about their experience at 0, 4, and 12 weeks.
The Purpose
This study is useful to understand volunteers' experience from product use, while it lacks rigorous scientific credentials, it helps to ensure that a person's experience aligns with the scientific results.
The Results
- 98% gentle
- 93% nourished
- 93% healthier
- 86% fine lines reduction
- 86% more youthful
- 93% no irritation
Age Defence
1. Tested at the Cellular Level
Gene Expression Study
The Process
A total of five genes were selected for the expression studies, in addition to one control ‘house-keeping’ gene (GAPDH). The five genes were MMP1, PTGES and the senescence markers p21, p16 and GLB1. The expression levels of the five genes were normalised to the housekeeping gene GAPDH to give fold change values.
The Purpose
To determine the effects of a physiological dose of solar UV irradiation on gene expression in 3D full thickness living human skin models with and without Age Defence.
The Results
- Complete protection against UV-induced P21 expression
- Complete reduction of PTGES expression to baseline levels following UV exposure
- Prevents the UV-induced spike in MMP1
2. Measured on the Surface
Clinical Trial
The Process
Testing was conducted in two phases to assess both hydration and sun protection. The hydration assessment was an open, intra-individual clinical study involving 30 healthy volunteers. The product was applied to the subjects, and skin hydration was tracked using a highly sensitive Moisture Meter SC. Measurements were taken before application, immediately after, and at 8, 12, and 24-hour intervals to track sustained moisture. Separately, the sun protection capabilities were tested in-vitro using specialised ultraviolet transmittance analysers to measure how effectively the formula absorbs and blocks UVA and UVB rays.
The Purpose
The studies aimed to prove that the formula measurably moisturises the skin under clinical assessment while delivering reliable, broad-spectrum sun protection. By rigorously evaluating these skin properties under controlled conditions, the trials ensure the product provides genuine, documented benefits.
The Results
In the moisturisation study, 90% of subjects experienced an immediate increase in skin moisture , demonstrating a 60.8% improvement right after application. The formula also provided long-lasting hydration, significantly improving skin moisturisation for a full 24 hours, including a 22.3% improvement maintained at the 12-hour mark. Furthermore, the UV transmittance analysis confirmed that the cream achieves an in-vivo SPF of 50 and officially passes the standards for broad-spectrum protection.
3. Perceived in the Mirror
Consumer Trial
The Process
58 people are provided with the product to use for 4 weeks, volunteers are asked questions about their experience at 0, 1, and 4 weeks.
The Purpose
This study is useful to understand volunteers' experience from product use, while it lacks rigorous scientific credentials, it helps to ensure that a person's experience aligns with the scientific results.
The Results
- 91% Said their skin was nourished
- 81% Skin felt firmer
- 88% Skin looked healthier
- 88% Experienced all day hydration
- 88% Noticed a healthy glow & increased luminosity
- 88% Agreed the cream did not clog pores
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INGREDIENTS
Born from Prof. Griffiths’ core belief: true skin health relies on synergy, not just isolated ingredients. By precisely pairing a highly tolerable retinyl-ester with cell-communicating peptides, antioxidants, and multiple chains of hyaluronic acid, he engineered a formula where the ingredients actively amplify one another.
AM: Age Defence
Advanced Encapsulated UV Filters: High performance UV-filters that are encapsulated to ensure they provide all the benefits of chemical sunscreen filters without absorption. This makes them sensitive skin friendly and non-greasy.
Phytoshield DNA Repair: Photolyase and Endoneuclease act as a biological 'search and support' team that aids the skin's natural recovery from UV exposure.
Squalane & Antioxidants: Bio-identical hydration and pollution defence.
PM: Night Repair Therapy
Cell-communicating peptides: Supports collagen synthesis.
Retinyl-ester: Promotes skin renewal and cell turnover.
Multimolecular hyaluronic acid: Supports the barrier & improves the performance of other ingredients.
View full INCI
Age Defence: Aqua, Ethylhexyl Methoxycinnamate, Butyl Methoxydibenzoylmethane, Squalane, Glyceryl Citrate/Lactate/Linoleate/Oleate, Octocrylene, Butylene Glycol, Rubus Idaeus Seed Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glycerin, Maleated Soybean Oil Glyceryl/Octyldodecanol Esters, Plankton Extract, Micrococcus Lysate, Vaccinium Myrtillus Fruit Extract, Helianthus Annuus Seed Oil, Lecithin, Tocopherol, Polysorbate 60, Sodium Acrylates Copolymer, Ethylhexylglycerin, Sorbitan Isostearate, Citric Acid, Sodium Benzoate, Phenethyl Alcohol, Hydroxyacetophenone, Potassium Sorbate, Parfum, Geraniol, Limonene, Linalool, Sodium Hydroxide, Phenoxyethanol Night Repair Therapy: Aqua, Helianthus Annuus Seed Oil, Cetyl Alcohol, Cetearyl Alcohol, Cocos Nucifera Oil, Glycerin, Theobroma Cacao Seed Butter, Prunus Amygdalus Dulcis Oil, Glyceryl Stearate, Simmondsia Chinensis Seed Oil, PEG-100 Stearate, Hydrolyzed Tomato Skin, Vaccinium Myrtillus Fruit/Leaf Extract, Butylene Glycol, Niacinamide, Hydrolyzed Hyaluronic Acid, Tocopherol, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Retinyl Palmitate, Carbomer, Triethanolamine, Phenoxyethanol, Ethylhexylglycerin, Polysorbate 20, Sodium Lactate
HOW TO USE
How to Apply Your Night Repair Therapy
Night Repair Therapy is a concentrated formula, so a little goes a long way.
How to apply:
- Use a pea-sized amount for the entire face and neck
- Warm between fingertips, then gently smooth into the skin
When to use:
- Apply every evening as the final step in your routine
- Use after cleansing (and after any optional serums, if desired)
How to Apply Your Age Defence
For best results, we recommend the multi-dot technique to ensure even, full coverage across the face and neck.
How to apply:
- Dispense 3–4 pumps of Age Defence
- Dot the product evenly across your face and neck (forehead, cheeks, chin, nose, and neck)
- Gently smooth into the skin until fully absorbed
When to use:
- Apply every morning as the final step in your skincare routine
- Always apply to clean skin
- Designed to protect and hydrate throughout the day with SPF 50
FAQs
Does Age Defence protect against infrared (IR) radiation?
Infrared (IR) radiation (especially IR-A) penetrates deeper into the skin than UV or blue light, contributing to heat stress, oxidative damage and accelerated skin ageing.
Infrared radiation cannot be blocked by traditional sunscreen filters, physical or chemical. There are currently no approved cosmetic ingredients that reflect or absorb infrared light in the way sunscreen filters protect against UV. Skincare products support the skin’s resilience to infrared-induced stress through actives. Age Defence contains a powerful antioxidant complex including: tocopherol (vitamin E), carotenoids, polyphenols and DNA repair enzymes. These ingredients don’t block IR but help defend against oxidative stress, inflammation and mitochondrial damage that IR exposure can trigger.
We’ve chosen not to make the “infrared protection” claim because no skincare product can truly block infrared.
Does Age Defence provide blue light protection?
Blue light (HEVL, 400–500 nm) is part of the visible light spectrum and cannot be effectively blocked by transparent skincare formulations. Only products containing visible light–reflective ingredients, such as iron oxides, provide real HEVL protection. This means true blue light protection requires ingredients that physically reflect visible light.
Antioxidants can help mitigate the damage caused by blue light. Age Defence contains carotenoids, polyphenols and vitamin E to help mitigate oxidative stress caused by blue light and support the skin’s natural defence and repair mechanisms This means our formulation helps skin recover from blue light exposure, but it does not block blue light itself.
That’s why we’ve chosen not to make a “blue light protection” claim, even though we could have.
Does it pair well with Night Repair Therapy?
Absolutely! Night Repair Therapy and Age Defence are our hardworking duo that keeps your skin in a state of protection and repair day or night.
Does it work well under makeup?
Yes, it sits beautifully under makeup offering all-day hydration. Can be worn alone or under makeup.
Can I use another antioxidant alongside Age Defence?
If you want to, you can use a separate antioxidant product before applying the day cream. However, it’s been designed to offer antioxidant protection as your one-step daytime cream.
What is flocculation?
When you apply sunscreen, many experience flocculation issues (probably without realising it). This means that, despite your best efforts, your application isn’t always even and can clump together. Using encapsulated technology means the sunscreen applies like a protective film over the skin, reducing any gaps and forming a better UVA and UVB protection layer.
Why have you chosen a mildly scented formulation?
The base ingredients, especially the repair enzymes have a distinctive smell. We added a very small amount of fragrance to boost the experience of using this daily.
Is it safe for sensitive skin?
Our day cream has been shown in independent clinical testing to be suitable for sensitive skin. Our encapsulated filter technology means the sunscreen filters themselves are not in contact with the skin making it suitable for those who are sometimes sensitised by sunscreen filters.
The formulation is mildly fragranced so if you are concerned about any specific allergies or irritation we recommend trialing a small amount first.
Will the DNA repair enzymes get rid of all my sun damage?
As much as we’d love to say yes, unfortunately not all of it. DNA Repair Enzymes can’t erase all past DNA repair, but it can mitigate some DNA damage, helping to correct UV-induced errors before they cause permanent cellular changes. In turn, this also helps reduce the risk of precancerous skin changes.
Is Age Defence a sunscreen?
Age Defence is a day cream that contains broad spectrum sunscreen filters meaning you can wear it as a sunscreen. We just recommend applying a 2 finger length amount to ensure adequate protection and it’s important to reapply throughout the day.
I think I’ve had a reaction to your cream. What shall I do?
We’re very sorry to hear you may have had a reaction to our cream. This is unusual and rare. Please stop use of the product. If you bought the product via our website please contact our patient experience team info@theskindiary.com or call us on 07477 010758 to discuss your concerns. If you bought via your local stockist please contact them directly for advice.
Do you have samples that I can try?
Unfortunately, we don’t offer product samples currently. We encourage you to visit one of our stockists so you can test our products in person. To find out who our stockists are please reach out to us - info@theskindiary.com
The smell is a bit stronger than usual – should I still use it?
Yes, if your product is within date and looks and feels as it should, a slightly stronger scent is nothing to worry about. But if you’re ever unsure, feel free to get in touch. Our team is happy to advise.
My product smells slightly different than last time – is that normal?
Yes, that’s completely normal. Our Night Repair Therapy is made with potent natural ingredients, which can have subtle variations in scent from batch to batch. These variations occur because many of our ingredients are plant-based and harvested seasonally. Due to factors like climate, rainfall, and soil conditions, the harvest timing may vary slightly each year, affecting the aroma natural extracts. This is a normal part of working with high-quality botanical actives, it’s nature’s fingerprint.
Will Night Repair Therapy make my skin peel or dry out?
No. The formula is specifically designed to minimise irritation, including dryness or peeling. The retinyl ester used in Night Repair Therapy is a milder form of retinoid that offers all the powerful benefits without the irritation often associated with traditional retinoids.
Where can I buy Night Repair Therapy?
You can purchase Night Repair Therapy directly through our website. Click on the "Buy Now" button to start your journey to healthy, rejuvenated skin.
What type of clinical testing has been done on Night Repair Therapy?
Night Repair Therapy has undergone rigorous double-blind, placebo-controlled clinical trials in human skin. These studies demonstrated its ability to significantly increase collagen and elastin production, crucial for reducing wrinkles and improving skin firmness.
How do I use Night Repair Therapy?
Apply a pea-sized amount of Night Repair Therapy to cleansed skin in the evening, focusing on areas with visible signs of ageing.
Is Night Repair Therapy tested on animals?
No. Night Repair Therapy is cruelty-free and has not been tested on animals. Our commitment to ethical testing aligns with our goal to deliver results without compromising on quality or integrity.
How does Night Repair Therapy renew the skin?
The formula contains peptides and retinyl ester, which stimulate collagen and elastin production while promoting cellular turnover. Hyaluronic acid (in two different molecular weights) helps to maintain skin elasticity and moisture levels, providing a plump, youthful appearance.
What are the key ingredients in Night Repair Therapy?
Night Repair Therapy features a blend of peptides, retinyl ester, bilberry, hydrolysed tomato skin, two chains of hyaluronic acid. These ingredients work together to protect, renew, and restore the skin for optimal anti-ageing results.
Can I use Night Repair Therapy with other skincare products?
Absolutely. Night Repair Therapy easily integrates into your existing skincare routine or with our personalised routines: Chapters. Night Repair Therapy is best used after cleansing.
Is Night Repair Therapy suitable for sensitive skin?
Yes. Night Repair Therapy is designed to deliver powerful anti-ageing benefits without irritation, making it suitable for sensitive skin types. The unique formula combines active ingredients with soothing botanicals like bilberry and hydrolysed tomato skin to minimise risk of irritation.
How long does it take to see results with Night Repair Therapy?
You can expect to see visible improvements in your skin within 3 months of consistent use and continued improvement in the months following. Clinical studies show significant increases in collagen and elastin levels, which are key to reversing signs of ageing.
What makes Night Repair Therapy different from other anti-ageing creams?
Night Repair Therapy uses a unique three-step approach: protecting healthy cells, renewing damaged ones, and restoring the skin barrier. Unlike other retinoid products, it delivers results without irritation thanks to its carefully balanced blend of peptides, retinyl-ester, antioxidants, and advanced delivery mechanisms. It's been tested in double-blind, placebo-controlled clinical trials, ensuring its effectiveness.
I am sensitive to retinoids, will I be okay with Night Repair Therapy?
Our rigorous testing showed Night Repair Therapy to be well-tolerated for sensitive skin and retinoid sensitivity. However, everyone's skin is unique so if you're allergic to or have questions about specific ingredients, please reach out to our team who are happy to help.
Can I use Night Repair Therapy every night?
Yes, we encourage you to use it every night to see best results.
Can I use Night Repair Therapy while pregnant or breastfeeding?
Night Repair Therapy is not safe for breastfeeding due to the inclusion of retinoids in the formula.
Are all costmetic products tested on human skin?
No, many products aren't tested on human skin, which is why Night Repair Therapy is so unique.
How do I know it works?
By the rigorous testing we carry out. Night Repair Therapy has been held to the highest standard of scientific testing. Double-blind, placebo-controlled clinical studies in human skin.
Our Standard
Cell-to-Surface™
We believe our testing should match the ambition of the formula.
For our products designed to drive profound, lasting changes to your skin health, we test the final formulation across three distinct dimensions before it ever reaches your routine:
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Tested at the Cell
Biological Validation
We measure deep beneath the surface to ensure the formula actively supports your skin’s long-term structural health.
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Measured on the Surface
Clinical Proof
We use advanced scientific instruments in independent trials to objectively track and quantify visible improvements.
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Perceived in the Mirror
Consumer Validation
Science only matters if you can see the difference. We use independent user panels to confirm our deep cellular research translates into real-world, visible confidence.
A Global authority in skin ageing
Two Pillars of Medical Expertise
This duo is the culmination of decades of specialised dermatological research, bringing together two distinct areas of medical expertise into one routine:
SKIN AGEING PIONEER: PROF. CHRIS GRIFFITHS OBE.
SKIN AGEING PIONEER: PROF. CHRIS GRIFFITHS OBE.
NOBEL PRIZE–INSPIRED SKIN SCIENCE
NOBEL PRIZE–INSPIRED SKIN SCIENCE
DEEP RESULTS TAKE TIME TO BUILD
What to Expect
1 Week
THE SURFACE RESULT
Immediate hydration. You will experience a flawless, velvet-matte finish during the day, and wake up to a softer, deeply nourished texture—without the redness typically expected from retinol.
1 Month
The calmed barrier
As daily inflammation is mitigated and nighttime repair is supported, your skin barrier becomes highly resilient. Your complexion looks settled, vibrant, and feels firmer to the touch.
3 Months
The Synergy Milestone
Because your daytime cream is actively stopping UV damage, your nighttime treatment is no longer fighting an uphill battle. The compounding cellular support reveals a statistically significant reduction in the appearance of wrinkles.
6 Months
Profound, Lasting Health
Your skin’s biological ecosystem is consistently supported 24/7. You will maintain sustained visible firmness, a resilient barrier, and an ongoing daily defence against environmental stress.
Before I started with Skin Diary it was a mind field with products. I wanted anti wrinkle, skin smoothing , glowing skin, clear pores. In order for this i needed 4 different serums,.and some did not mix well together. One product, it may appear expensive but if you add serums and moisturiser you were using it may some in more expensive.
I have tried many, many night creams over my 64 years but The Skin Diary is amazing. Just one product, I even use it under my eyes, at night and that’s it. Beautiful skin.
I was curious after viewing the social media posts. Having tried retinol and vitamin C serums, both of which irritated my skin, the lure of the same results using a simplified system was exciting. The day cream feels great on the skin, two pumps of the product seems to be the right amount for my face. Used it regularly throughout the day on holiday in Spain, my face felt well protected and perfectly moisturised. It is expensive and I am concerned that the tube won’t last long making it a costly purchase every 6 or so weeks. Every 2 months would be better. Overall, very happy with the Day Cream.
Have been using Night Repair for a few months and have found it really suits my sensitive skin - retinol is just too harsh for me. Have always used a moisturiser and separate sunscreen so thought Age Defence was probably not essential...and also quite expensive for a day cream. However, I did want to try it so bought it as a treat.....and am slightly sorry to find that it really does seem to enhance the results of the Night Repair cream, my face feels comfortable all day and it sits really well under make up (which am now wearing less of). Just using one cream for day and one for night also appeals to my puritan heart, so will have to keep using the damn stuff now....
I’m generally sceptical of the latest miracle cream. However, in this instance, the seduction was threefold. The credentials of the development team, an evidence base with tissue sampling and the appeal of one and done. I’m just bout to finish my first pots of both day and night creams and while there haven’t been any miracles to date, they both feel good on my skin and I am willing to persevere. I remain cautiously optimistic.