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The Ultimate Skin Ageing Duo

The Ultimate Skin Ageing Duo

Simplify your skincare with a complete AM and PM routine in two powerful steps.

Daily protection against accelerated skin ageing in a beautifully formulated, deeply nourishing single step morning routine combined with our award-winning night cream - proven to be 20x more effective than retinol, without the Irritation.

  • Skincare Simplified: A complete, high-performance daily routine in two elegant steps.
  • 24-Hour Synergy: Protects your progress by day; supports deep structural renewal by night.
  • Clinically Proven: Validated at the cellular level to protect collagen and visibly reduce wrinkles.
  • Sensitive Skin Safe: Clinical-grade actives engineered to strengthen your barrier.
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MULTI-AWARD WINNING RESULTS

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The Ultimate Skin Ageing Duo

£227.00 GBP

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KEY BENEFITS

AM: Protects & Preserves

Age Defence is clinically proven to protect against daily collagen degradation, inflammation, and environmental stress. It locks in your nighttime results while providing invisible, encapsulated UV defence.[1]

PM: Renews & Strengthens

Night Repair Therapy delivers advanced cellular support—up to 20x more effectively than standard retinol,  without the visible irritation commonly associated with retinoids.[2]

Supports Natural Recovery

Advanced daytime DNA repair enzymes meet nighttime cell-communicating peptides to foster continuous, 24-hour biological support.[3]

Deep, 24/7 Hydration

Enjoy an invisible, velvet-matte finish under your morning makeup, and deeply nourishing, barrier-restoring moisture while you sleep.[4]
View Citations
[1] In skin exposed to solar-simulated UV radiation, Age Defence reduced MMP1, PTGES, and P21 expression. [2] Independently proven at via the manchester patch test assay to outperform the control (equivalent 20x efficacy of retinol). [3] Emanuele, E., Spencer, J. M., & Braun, M. (2014). Topical Application of Preparations Containing DNA Repair Enzymes Prevents Ultraviolet-Induced Telomere Shortening and c-FOS Proto-Oncogene Hyperexpression in Human Skin: An Experimental Pilot Study. Journal of Drugs in Dermatology (JDD), 13(3), 304-309. [4] Proven in an independent clincial study to provide 24 hour hydration

The Cumulative Impact of UV and Environmental Stress

Throughout the day, the skin is constantly exposed to a complex web of environmental aggressors, predominantly UV radiation, but also urban pollution, infrared, and high-energy visible (HEV) blue light. While a single day of exposure may not show immediate visible consequences, the biological impact is profound.

These daily stressors trigger an influx of free radicals and microscopic, invisible inflammation within the skin’s deeper layers. Over months and years, this daily micro-damage compounds. It slowly degrades the skin's structural proteins (collagen and elastin) and compromises the lipid barrier, ultimately manifesting as the visible signs of mature skin: loss of firmness, dullness, and fine lines. By successfully mitigating this daily onslaught, the compounding cycle of environmental damage is halted, allowing the skin to retain its structural integrity over time.

The Biology of Night-time Renewal

The human body operates on a strict circadian rhythm, and the skin is no exception. While the daytime is focused on defending against environmental stress, the nighttime is when the skin's biological ecosystem shifts entirely into 'recovery mode'. Blood flow increases, cellular turnover accelerates, and the natural synthesis of fresh structural proteins peaks.

However, as the skin matures, these natural repair processes begin to slow down. The typical 28-day renewal cycle gradually lengthens, meaning older cells remain on the surface for longer, contributing to the appearance of fine lines.

At the same time, the biological signals that stimulate collagen production become less active, leading to a gradual loss of structural density within the skin.Supporting these natural pathways is key to helping the skin maintain its ability to repair, renew, and function optimally over time.

An Interconnected Biological Ecosystem

It is easy to think of the skin as a simple protective barrier, but it is actually a highly intelligent, deeply interconnected communication network. Beneath the surface, skin cells constantly send and receive biological signals to one another, often via specific proteins and peptides, to maintain the skin's cohesive architecture.

When this communication network is functioning optimally, the skin's structural foundation remains resilient, bouncy, and vibrant. However, environmental damage, chronic inflammation, and the natural ageing process can scramble these vital signals. By fostering a consistently protected and deeply nourished environment around the clock, this intricate cellular dialogue is supported. This allows the skin's ecosystem to function harmoniously, acting as a unified, highly resilient shield 24 hours a day.

As Featured In

  • BEFOREAFTER
  • BEFOREAFTER
  • BEFOREAFTER
  • BEFOREAFTER
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PURE SCIENCE. PROVEN RESULTS

Proven Results

Rigorously tested across all three dimensions of our Cell-to-Surface™ standard

Tested at the Cell

BIOLOGICAL EFFICACY


AM: 3.7x Reduction in collagen damage.
AM: 3.8x Reduction in inflammation.
PM: 2x Increase in collagen & elastic fibres.

*AM: In skin exposed to solar-simulated UV radiation, Age Defence reduced the expression of key biomarkers associated with collagen degradation, inflammation, compared to untreated UV-exposed controls. PM: Proven in independent Manchester Patch Test Assay at the university of Manchester

Measured on the Surface

CLINICAL STUDY


AM: 24hr All day hydration
PM: 7 Days Significant Reduction in wrinkles in as little as 7 days

* Proven in independent clinical trials

Perceived in the Mirror

Consumer Validated


98% Said the routine was gentle on their skin.
93% Felt their skin was significantly nourished

* Proven in independent consumer studies

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INGREDIENTS

Born from Prof. Griffiths’ core belief: true skin health relies on synergy, not just isolated ingredients. By precisely pairing a highly tolerable retinyl-ester with cell-communicating peptides, antioxidants, and multiple chains of hyaluronic acid, he engineered a formula where the ingredients actively amplify one another.


AM: Age Defence

Advanced Encapsulated UV Filters: High-performance, non-absorbing broad-spectrum defence.

Phytoshield DNA Repair: A biological 'search and support' team aiding recovery from UV exposure.

Squalane & Antioxidants: Bio-identical hydration and pollution defence.


PM: Night Repair Therapy

Cell-communicating peptides: Supports collagen synthesis.

Retinyl-ester: Visibly regenerates skin and promotes cell turnover.

Multi-molecular Hyaluronic Acid:Deeply restores moisture and strengthens the skin barrier.

View full INCI's

Age Defence: Aqua, Ethylhexyl Methoxycinnamate, Butyl Methoxydibenzoylmethane, Squalane, Glyceryl Citrate/Lactate/Linoleate/Oleate, Octocrylene, Butylene Glycol, Rubus Idaeus Seed Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glycerin, Maleated Soybean Oil Glyceryl/Octyldodecanol Esters, Plankton Extract, Micrococcus Lysate, Vaccinium Myrtillus Fruit Extract, Helianthus Annuus Seed Oil, Lecithin, Tocopherol, Polysorbate 60, Sodium Acrylates Copolymer, Ethylhexylglycerin, Sorbitan Isostearate, Citric Acid, Sodium Benzoate, Phenethyl Alcohol, Hydroxyacetophenone, Potassium Sorbate, Parfum, Geraniol, Limonene, Linalool, Sodium Hydroxide, Phenoxyethanol

Night Repair Therapy: Aqua, Helianthus Annuus Seed Oil, Cetyl Alcohol, Cetearyl Alcohol, Cocos Nucifera Oil, Glycerin, Theobroma Cacao Seed Butter, Prunus Amygdalus Dulcis Oil, Glyceryl Stearate, Simmondsia Chinensis Seed Oil, PEG-100 Stearate, Hydrolyzed Tomato Skin, Vaccinium Myrtillus Fruit/Leaf Extract, Butylene Glycol, Niacinamide, Hydrolyzed Hyaluronic Acid, Tocopherol, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Retinyl Palmitate, Carbomer, Triethanolamine, Phenoxyethanol, Ethylhexylglycerin, Polysorbate 20, Sodium Lactate

HOW TO USE

How to apply Night Repair Therapy

How to Apply Your Night Repair Therapy

Night Repair Therapy is a concentrated formula, so a little goes a long way.

How to apply:

  • Use a pea-sized amount for the entire face and neck
  • Warm between fingertips, then gently smooth into the skin

When to use

  • Apply every evening as the final step in your routine
  • Use after cleansing (and after any optional serums, if desired)
How to apply Age Defence

How to Apply Your Age Defence

For best results, we recommend the multi-dot technique to ensure even, full coverage across the face and neck.

How to apply:

  • Dispense 3–4 pumps of Age Defence
  • Dot the product evenly across your face and neck (forehead, cheeks, chin, nose, and neck)
  • Gently smooth into the skin until fully absorbed

When to use:

  • Apply every morning as the final step in your skincare routine
  • Always apply to clean skin
  • Designed to protect and hydrate throughout the day with SPF 50

FAQs

Does Age Defence protect against infrared (IR) radiation?

Infrared (IR) radiation (especially IR-A) penetrates deeper into the skin than UV or blue light, contributing to heat stress, oxidative damage and accelerated skin ageing.

Infrared radiation cannot be blocked by traditional sunscreen filters, physical or chemical. There are currently no approved cosmetic ingredients that reflect or absorb infrared light in the way sunscreen filters protect against UV. Skincare products support the skin’s resilience to infrared-induced stress through actives. Age Defence contains a powerful antioxidant complex including: tocopherol (vitamin E), carotenoids, polyphenols and DNA repair enzymes. These ingredients don’t block IR but help defend against oxidative stress, inflammation and mitochondrial damage that IR exposure can trigger.


We’ve chosen not to make the “infrared protection” claim because no skincare product can truly block infrared.

Does Age Defence provide blue light protection?

Blue light (HEVL, 400–500 nm) is part of the visible light spectrum and cannot be effectively blocked by transparent skincare formulations. Only products containing visible light–reflective ingredients, such as iron oxides, provide real HEVL protection. This means true blue light protection requires ingredients that physically reflect visible light.

Antioxidants can help mitigate the damage caused by blue light. Age Defence contains carotenoids, polyphenols and vitamin E to help mitigate oxidative stress caused by blue light and support the skin’s natural defence and repair mechanisms This means our formulation helps skin recover from blue light exposure, but it does not block blue light itself.

That’s why we’ve chosen not to make a “blue light protection” claim, even though we could have.

Does it pair well with Night Repair Therapy?

Absolutely! Night Repair Therapy and Age Defence are our hardworking duo that keeps your skin in a state of protection and repair day or night.

Does it work well under makeup?

Yes, it sits beautifully under makeup offering all-day hydration. Can be worn alone or under makeup.

Can I use another antioxidant alongside Age Defence?

If you want to, you can use a separate antioxidant product before applying the day cream. However, it’s been designed to offer antioxidant protection as your one-step daytime cream.

What is flocculation?

When you apply sunscreen, many experience flocculation issues (probably without realising it). This means that, despite your best efforts, your application isn’t always even and can clump together. Using encapsulated technology means the sunscreen applies like a protective film over the skin, reducing any gaps and forming a better UVA and UVB protection layer.

Why have you chosen a mildly scented formulation?

The base ingredients, especially the repair enzymes have a distinctive smell. We added a very small amount of fragrance to boost the experience of using this daily.

Is it safe for sensitive skin?

Our day cream has been shown in independent clinical testing to be suitable for sensitive skin. Our encapsulated filter technology means the sunscreen filters themselves are not in contact with the skin making it suitable for those who are sometimes sensitised by sunscreen filters. 

The formulation is mildly fragranced so if you are concerned about any specific allergies or irritation we recommend trialing a small amount first.

Will the DNA repair enzymes get rid of all my sun damage?

As much as we’d love to say yes, unfortunately not all of it. DNA Repair Enzymes can’t erase all past DNA repair, but it can mitigate some DNA damage, helping to  correct UV-induced errors before they cause permanent cellular changes. In turn, this also helps reduce the risk of precancerous skin changes.

Is Age Defence a sunscreen?

Age Defence is a day cream that contains broad spectrum sunscreen filters meaning you can wear it as a sunscreen. We just recommend applying a 2 finger length amount to ensure adequate protection and it’s important to reapply throughout the day.

I think I’ve had a reaction to your cream. What shall I do?

We’re very sorry to hear you may have had a reaction to our cream. This is unusual and rare. Please stop use of the product. If you bought the product via our website please contact our patient experience team info@theskindiary.com or call us on 07477 010758 to discuss your concerns. If you bought via your local stockist please contact them directly for advice.

Do you have samples that I can try?

Unfortunately, we don’t offer product samples currently. We encourage you to visit one of our stockists so you can test our products in person. To find out who our stockists are please reach out to us - info@theskindiary.com

The smell is a bit stronger than usual – should I still use it?

Yes, if your product is within date and looks and feels as it should, a slightly stronger scent is nothing to worry about. But if you’re ever unsure, feel free to get in touch. Our team is happy to advise.

My product smells slightly different than last time – is that normal?

Yes, that’s completely normal. Our Night Repair Therapy is made with potent natural ingredients, which can have subtle variations in scent from batch to batch. These variations occur because many of our ingredients are plant-based and harvested seasonally. Due to factors like climate, rainfall, and soil conditions, the harvest timing may vary slightly each year, affecting the aroma natural extracts. This is a normal part of working with high-quality botanical actives, it’s nature’s fingerprint.

Will Night Repair Therapy make my skin peel or dry out?

No. The formula is specifically designed to minimise irritation, including dryness or peeling. The retinyl ester used in Night Repair Therapy is a milder form of retinoid that offers all the powerful benefits without the irritation often associated with traditional retinoids.

Where can I buy Night Repair Therapy?

You can purchase Night Repair Therapy directly through our website. Click on the "Buy Now" button to start your journey to healthy, rejuvenated skin.

What type of clinical testing has been done on Night Repair Therapy?

Night Repair Therapy has undergone rigorous double-blind, placebo-controlled clinical trials in human skin. These studies demonstrated its ability to significantly increase collagen and elastin production, crucial for reducing wrinkles and improving skin firmness.

How do I use Night Repair Therapy?

Apply a pea-sized amount of Night Repair Therapy to cleansed skin in the evening, focusing on areas with visible signs of ageing.

Is Night Repair Therapy tested on animals?

No. Night Repair Therapy is cruelty-free and has not been tested on animals. Our commitment to ethical testing aligns with our goal to deliver results without compromising on quality or integrity.

How does Night Repair Therapy renew the skin?

The formula contains peptides and retinyl ester, which stimulate collagen and elastin production while promoting cellular turnover. Hyaluronic acid (in two different molecular weights) helps to maintain skin elasticity and moisture levels, providing a plump, youthful appearance.

What are the key ingredients in Night Repair Therapy?

Night Repair Therapy features a blend of peptides, retinyl ester, bilberry, hydrolysed tomato skin, two chains of hyaluronic acid. These ingredients work together to protect, renew, and restore the skin for optimal anti-ageing results.

Can I use Night Repair Therapy with other skincare products?

Absolutely. Night Repair Therapy easily integrates into your existing skincare routine or with our personalised routines: Chapters. Night Repair Therapy is best used after cleansing.

Is Night Repair Therapy suitable for sensitive skin?

Yes. Night Repair Therapy is designed to deliver powerful anti-ageing benefits without irritation, making it suitable for sensitive skin types. The unique formula combines active ingredients with soothing botanicals like bilberry and hydrolysed tomato skin to minimise risk of irritation.

How long does it take to see results with Night Repair Therapy?

You can expect to see visible improvements in your skin within 3 months of consistent use and continued improvement in the months following. Clinical studies show significant increases in collagen and elastin levels, which are key to reversing signs of ageing.

What makes Night Repair Therapy different from other anti-ageing creams?

Night Repair Therapy uses a unique three-step approach: protecting healthy cells, renewing damaged ones, and restoring the skin barrier. Unlike other retinoid products, it delivers results without irritation thanks to its carefully balanced blend of peptides, retinyl-ester, antioxidants, and advanced delivery mechanisms. It's been tested in double-blind, placebo-controlled clinical trials, ensuring its effectiveness.

I am sensitive to retinoids, will I be okay with Night Repair Therapy?

Our rigorous testing showed Night Repair Therapy to be well-tolerated for sensitive skin and retinoid sensitivity. However, everyone's skin is unique so if you're allergic to or have questions about specific ingredients, please reach out to our team who are happy to help.

Can I use Night Repair Therapy every night?

Yes, we encourage you to use it every night to see best results.

Can I use Night Repair Therapy while pregnant or breastfeeding?

Night Repair Therapy is not safe for breastfeeding due to the inclusion of retinoids in the formula.

Are all costmetic products tested on human skin?

No, many products aren't tested on human skin, which is why Night Repair Therapy is so unique.

How do I know it works?

By the rigorous testing we carry out. Night Repair Therapy has been held to the highest standard of scientific testing. Double-blind, placebo-controlled clinical studies in human skin.

Our Standard

Cell-to-Surface™

We believe our testing should match the ambition of the formula. 

For our products designed to drive profound, lasting changes to your skin health, we test the final formulation across three distinct dimensions before it ever reaches your routine:

  • Tested at the Cell

    Biological Validation

    We measure deep beneath the surface to ensure the formula actively supports your skin’s long-term structural health.

  • Measured on the Surface

    Clinical Proof

    We use advanced scientific instruments in independent trials to objectively track and quantify visible improvements.

  • Perceived in the Mirror

    Consumer Validation

    Science only matters if you can see the difference. We use independent user panels to confirm our deep cellular research translates into real-world, visible confidence.

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A Global authority in skin ageing

Two Pillars of Medical Expertise

This duo is the culmination of decades of specialised dermatological research, bringing together two distinct areas of medical expertise into one routine:

SKIN AGEING PIONEER: PROF. CHRIS GRIFFITHS OBE.

As one of the world’s most distinguished consultant dermatologists, Prof. Griffiths helped discover exactly how topical retinoids impact aged skin. Night Repair Therapy harnesses his deep understanding of retinoid pathways to deliver profound, clinical-grade results without irritation.

NOBEL PRIZE–INSPIRED SKIN SCIENCE

Engineered with the clinical insight of skin cancer specialist Dr. Clare Kiely, Age Defence utilises enzymes such as photolyase and endonuclease—inspired by the biological pathways described in DNA repair research recognised by the 2015 Nobel Prize in Chemistry, to support the skin’s natural recovery processes following UV exposure.

DEEP RESULTS TAKE TIME TO BUILD

What to Expect

1 Week

THE SURFACE RESULT

Immediate hydration. You will experience a flawless, velvet-matte finish during the day, and wake up to a softer, deeply nourished texture—without the redness typically expected from retinol.

1 Month

The calmed barrier

As daily inflammation is mitigated and nighttime repair is supported, your skin barrier becomes highly resilient. Your complexion looks settled, vibrant, and feels firmer to the touch.

3 Months

The Synergy Milestone

Because your daytime cream is actively stopping UV damage, your nighttime treatment is no longer fighting an uphill battle. The compounding cellular support reveals a statistically significant reduction in the appearance of wrinkles.

6 Months

Profound, Lasting Health

Your skin’s biological ecosystem is consistently supported 24/7. You will maintain sustained visible firmness, a resilient barrier, and an ongoing daily defence against environmental stress.