Product Studies
Night Repair Therapy
BEFORE
Manchester Patch Test Assay
Test Type
Clinical studies assessing biomarkers in human skin—via human biopsies, 3D skin models, or explants—using controlled and intra-patient methodologies
Process
Intra-subject controlled, double-blinded study on human volunteers with skin biopsies taken and biomarkers examined under microscope. Validated & benchmarked against tretinoin.
Purpose
Rapidly models 6 months of use on live human skin
Results
Outperformed gold standard (equivalent 20x more effective than retinol)
2x
increase in collagen
2x
increase in fibrillin
BEFORE
Night Repair Therapy
Clinical Trial
Test Type
Non-Invasive Clinical Trial
Process
29 people have baseline professional Visioscan in controlled conditions to measure wrinkle depth, images are taken before using the product, at 7 days, 4 weeks and 12 weeks. Computer-measured wrinkles are compared to the baseline.
Purpose
A good study to see if visual improvements are obtained from use of the product
Results
Significant reduction in wrinkles with statistical significance of p=0.0004
Night Repair Therapy
Consumer Trial
Test Type
Consumer Trial
Process
44 people are provided with the product to use for 12 weeks, volunteers are asked questions about their experience at 0, 4, and 12 weeks.
Purpose
This study is useful to understand volunteers’ experience from product use, while it lacks rigorous scientific credentials, it helps to ensure that a person's experience aligns with the scientific results.
Results
98%
Said the product was gentle on their skin
93%
Felt their skin was significantly nourished after use
86%
Said their skin looked healthier
86%
Noticed a reduction in fine lines
Age Defence
BEFORE
BEFORE
BEFORE
Gene Expression Study
Test Type
Scientific biomarker randomised controlled clinical trials
Process
A total of five genes were selected for the expression studies, in addition to one control ‘house-keeping’ gene (GAPDH). The five genes were MMP1, PTGES and the senescence markers p21, p16 and GLB1. The expression levels of the five genes were normalised to the housekeeping gene GAPDH to give fold change values.
Purpose
To determine the effects of a physiological dose of solar UV irradiation on gene expression in 3D full thickness living human skin models with and without Age Defence
Results
Complete protection against UV-induced P21 expression
Complete reduction of PTGES expression to baseline levels following UV exposure
Prevents the UV-induced spike in MMP1
Age Defence
Clinical Trial
Test Type
Non-Invasive Clinical Trial
Process
Testing was conducted in two phases to assess both hydration and sun protection. The hydration assessment was an open, intra-individual clinical study involving 30 healthy volunteers. The product was applied to the subjects, and skin hydration was tracked using a highly sensitive Moisture Meter SC. Measurements were taken before application, immediately after, and at 8, 12, and 24-hour intervals to track sustained moisture. Separately, the sun protection capabilities were tested in vitro using specialized ultraviolet transmittance analyzers to measure how effectively the formula absorbs and blocks UVA and UVB rays.
Purpose
The studies aimed to prove that the formula measurably moisturises the skin under clinical assessment while delivering reliable, broad-spectrum sun protection. By rigorously evaluating these skin properties under controlled conditions, the trials ensure the product provides genuine, documented benefits.
Results
In the moisturisation study, 90% of subjects experienced an immediate increase in skin moisture , demonstrating a 60.8% improvement right after application. The formula also provided long-lasting hydration, significantly improving skin moisturisation for a full 24 hours, including a 22.3% improvement maintained at the 12-hour mark. Furthermore, the UV transmittance analysis confirmed that the cream achieves an in vivo SPF of 50 and officially passes the standards for broad-spectrum protection.
Age Defence
Consumer Trial
Test Type
Consumer Trial
Process
58 people are provided with the product to use for 4 weeks, volunteers are asked questions about their experience at 0, 1, and 4 weeks.
Purpose
This study is useful to understand volunteers’ experience from product use, while it lacks rigorous scientific credentials, it helps to ensure that a person's experience aligns with the scientific results.
Results
91%
Said their skin felt nourished
81%
Noticed firmer skin
88%
Noticed a healthy glow & increased luminosity
88%
Experienced all day hydration