The Ultimate Skin Ageing Duo
Skin Health Simplified
Created by consultant dermatologists, The Ultimate Skin Longevity Duo is a complete AM and PM skincare solution, designed to protect your skin by day and repair it at night.
The Skin Diary formulations are clinically proven to defend against UV and environmental stressors, support cellular repair, and restore the skin’s barrier function.
- Regular price
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£227.00 - Regular price
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- Sale price
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£227.00
- Complete AM / PM Rotuine in two products
- Protect against UV and environmental stressors
- Repair skin at a cellular level
- Restore the skin’s barrier function
- Suitable for sensitive skin
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Age Defence - Day Cream
Deeply nourishing all-day hydration with DNA repair enzymes, antioxidants and encapsulated sunscreen, restoring youthful skin function by helping prevent cellular senescence, inflammation and the breakdown of collagen and fibrillin.
- Lightweight, all-day hydration with a non-greasy finish
- Helps to repair UV-induced DNA damage
- Encapsulated broad-spectrum SPF50 | PA++++
- Dermatologically approved
Prevents collagen and fibrilin breakdown - Can be worn alone or under makeup
- Active protection against UV-induced molecular ageing and oxidative stress
- Scientifically proven to protect against UV-induced gene expression changes linked to cellular senescence, inflammaging and collagen breakdown
- Suitable for sensitive skin
Night Repair Therapy - Night Cream
Reverse signs of ageing with clinically proven skin repair—without irritation.
- 20x more effective than retinol
- Boosts collagen and elastin for firmer, youthful skin
- Repairs sun damage and restores skin barrier health
- Developed by world-leading dermatologists
- Gentle, irritation-free formula suitable for sensitive skin
Born from decades of pioneering research by Professor Chris Griffiths OBE and Dr. Tamara Griffiths. With research conducted in skin biology and regenerative medicine, this powerful formulation is clinically proven to increase collagen and elastin production, resulting in youthful-looking skin.
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After

Clinically Proven Repair at Night
20x
More effective than retinols[1]2x
Increase in collagen[2]2x
Increase in fibrillin[2]Zero
IrritationClinically Proven
To reduce wrinkles [3][1] Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327-48. doi: 10.2147/ciia.2006.1.4.327. PMID: 18046911; PMCID: PMC2699641.
[2] Langton AK, McConnell JC, Cotterell LF, Halai P, Griffiths TW, Griffiths CEM, Watson REB. Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse (Night Repair Therapy), a novel over-the-counter anti-ageing product. J Eur Acad Dermatol Venereol. 2022 Jan;36(1):e43-e46. doi: 10.1111/jdv.17612. Epub 2021 Aug 30. PMID: 34416056.
[3] Independently proven on 29 people over 12 weeks p value 0.0004
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CREATED BY CONSULTANT DERMATOLOGISTS
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SCIENTIFICALLY PROVEN RESULTS
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MADE IN THE UK

Proven Daytime Protection
Prevents Cellular Senescence, Inflammation, and the Breakdown of Collagen and Fibrillin for Younger, Healthier Skin
We tested Age Defence with advanced gene expression testing in 3D human skin equivalents to measure its true impact on epigenetic ageing, cellular senescence and oxidative stress; three key biological pathways. This research was independently carried out by Professor Mark Birch-Machin, a Professor of molecular dermatology and widely recognised as a leading expert in UV-induced cellular damage to human skin and skin ageing.
The Results
Professor Birch Machin found:
Giving statistically significant protection against UV-induced P21 expression*
Complete reduction of PTGES expression to baseline levels following UV exposure*
Prevents the UV-induced spike in MMP1*
The Skin Diary Age Defence Moisturising Day Cream is proven for statistically significant protection against UV-induced epigenetic activity, supporting the role of our formula in modulating the skin’s biological ageing pathways.
The Skin Diary Age Defence Moisturising Day Cream is proven for statistically significant protection against UV-induced epigenetic activity, supporting the role of our formula in modulating the skin’s biological ageing pathways.
What is Cell Senescence
Cellular senescence is a key driver of ageing and one of the primary targets for skin regeneration. Senescent cells (or zombie cells) are retired; they stay alive but stop dividing and repairing themselves. These retired cells release inflammation, which can affect neighbouring cells.
They don’t function as they should, but they don’t die quietly, either. Instead, they hang around like a bad apple in a fruit down, slowly spreading dysfunction to the cells around them. This can result in a breakdown of collagen and elastin (fibrillin) production, inflammation, impaired skin cell renewal and age-related decline in regenerative capacity.
These ‘retired’ senescent cells build up and contribute to what we see as visible ageing. This molecular process starts a long time before the visible ageing appears, which is where prevention comes in. Minimising UV-induced cellular senescence in the skin is a great way to slow skin ageing.
What is Inflammageing?
Inflammageing is a slowly progressing, low-grade systemic inflammation that can lead to tissue damage and conditions associated with premature ageing. By focusing on protection from DNA repair enzymes, the goal is to reduce that inflammation and subsequent ageing factors.
Inflammageing is often considered a consequence of immunosenescence, which is the gradual decline of the immune system. A weakened immune system over time, limits the skin’s ability to repair itself and can lead to senescent cells, which increases overall inflammation. This creates an inflammatory environment, contributing to inflammageing.
Collagen & Fibrilins Role in Skin Ageing
Collagen is an abundant protein giving our skin its volume and strength. Fibrillin-rich microfibrils act as scaffolds for our skin’s elastic fibre formation, which is necessary for skin elasticity and resilience.
As we age, our collagen naturally degrades and our fibrillin can become damaged through various factors. They are not easily restored once the degradation has happened, but we do know that protection (sunscreen), retinoids (Night Repair Therapy) and restoration (DNA Repair Enzymes) work to restore both in photoaged skin.
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Night Repair TherapyNight Repair Therapy
- Regular price
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£135.00 - Regular price
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- Sale price
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£135.00
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The Ultimate Skin Ageing DuoThe Ultimate Skin Ageing Duo
- Regular price
-
£227.00 - Regular price
-
- Sale price
-
£227.00
Add to cart Quick view
FAQs
Does Age Defence protect against infrared (IR) radiation?
Infrared (IR) radiation (especially IR-A) penetrates deeper into the skin than UV or blue light, contributing to heat stress, oxidative damage and accelerated skin ageing.
Infrared radiation cannot be blocked by traditional sunscreen filters, physical or chemical. There are currently no approved cosmetic ingredients that reflect or absorb infrared light in the way sunscreen filters protect against UV. Skincare products support the skin’s resilience to infrared-induced stress through actives. Age Defence contains a powerful antioxidant complex including: tocopherol (vitamin E), carotenoids, polyphenols and DNA repair enzymes. These ingredients don’t block IR but help defend against oxidative stress, inflammation and mitochondrial damage that IR exposure can trigger.
We’ve chosen not to make the “infrared protection” claim because no skincare product can truly block infrared.
Does Age Defence provide blue light protection?
Blue light (HEVL, 400–500 nm) is part of the visible light spectrum and cannot be effectively blocked by transparent skincare formulations. Only products containing visible light–reflective ingredients, such as iron oxides, provide real HEVL protection. This means true blue light protection requires ingredients that physically reflect visible light.
Antioxidants can help mitigate the damage caused by blue light. Age Defence contains carotenoids, polyphenols and vitamin E to help mitigate oxidative stress caused by blue light and support the skin’s natural defence and repair mechanisms This means our formulation helps skin recover from blue light exposure, but it does not block blue light itself.
That’s why we’ve chosen not to make a “blue light protection” claim, even though we could have.
Does it pair well with Night Repair Therapy?
Absolutely! Night Repair Therapy and Age Defence are our hardworking duo that keeps your skin in a state of protection and repair day or night.
Does it work well under makeup?
Yes, it sits beautifully under makeup offering all-day hydration. Can be worn alone or under makeup.
Can I use another antioxidant alongside Age Defence?
If you want to, you can use a separate antioxidant product before applying the day cream. However, it’s been designed to offer antioxidant protection as your one-step daytime cream.
What is flocculation?
When you apply sunscreen, many experience flocculation issues (probably without realising it). This means that, despite your best efforts, your application isn’t always even and can clump together. Using encapsulated technology means the sunscreen applies like a protective film over the skin, reducing any gaps and forming a better UVA and UVB protection layer.
Why have you chosen a mildly scented formulation?
The base ingredients, especially the repair enzymes have a distinctive smell. We added a very small amount of fragrance to boost the experience of using this daily.
and designed a formula with the scent of a cream that you’ll look forward to applying every morning. It’s also a clinically proven mood-boosting scent to set your morning off right.
Is it safe for sensitive skin?
Our day cream has been shown in independent clinical testing to be suitable for sensitive skin. Our encapsulated filter technology means the sunscreen filters themselves are not in contact with the skin making it suitable for those who are sometimes sensitised by sunscreen filters.
The formulation is mildly fragranced so if you are concerned about any specific allergies or irritation we recommend trialing a small amount first.
Will the DNA repair enzymes get rid of all my sun damage?
As much as we’d love to say yes, unfortunately not all of it. DNA Repair Enzymes can’t erase all past DNA repair, but it can mitigate some DNA damage, helping to correct UV-induced errors before they cause permanent cellular changes. In turn, this also helps reduce the risk of precancerous skin changes.
Is Age Defence a sunscreen?
Age Defence is a day cream that contains broad spectrum sunscreen filters meaning you can wear it as a sunscreen. We just recommend applying a 2 finger length amount to ensure adequate protection and it’s important to reapply throughout the day.
I think I’ve had a reaction to your cream. What shall I do?
We’re very sorry to hear you may have had a reaction to our cream. This is unusual and rare. Please stop use of the product. If you bought the product via our website please contact our patient experience team info@theskindiary.com or call us on 07477 010758 to discuss your concerns. If you bought via your local stockist please contact them directly for advice.
Do you have samples that I can try?
Unfortunately, we don’t offer product samples currently. We encourage you to visit one of our stockists so you can test our products in person. To find out who our stockists are please reach out to us - info@theskindiary.com
The smell is a bit stronger than usual – should I still use it?
Yes, if your product is within date and looks and feels as it should, a slightly stronger scent is nothing to worry about. But if you’re ever unsure, feel free to get in touch. Our team is happy to advise.
My product smells slightly different than last time – is that normal?
Yes, that’s completely normal. Our Night Repair Therapy is made with potent natural ingredients, which can have subtle variations in scent from batch to batch. These variations occur because many of our ingredients are plant-based and harvested seasonally. Due to factors like climate, rainfall, and soil conditions, the harvest timing may vary slightly each year, affecting the aroma natural extracts. This is a normal part of working with high-quality botanical actives, it’s nature’s fingerprint.
Will Night Repair Therapy make my skin peel or dry out?
No. The formula is specifically designed to minimise irritation, including dryness or peeling. The retinyl ester used in Night Repair Therapy is a milder form of retinoid that offers all the powerful benefits without the irritation often associated with traditional retinoids.
Where can I buy Night Repair Therapy?
You can purchase Night Repair Therapy directly through our website. Click on the "Buy Now" button to start your journey to healthy, rejuvenated skin.
What type of clinical testing has been done on Night Repair Therapy?
Night Repair Therapy has undergone rigorous double-blind, placebo-controlled clinical trials in human skin. These studies demonstrated its ability to significantly increase collagen and elastin production, crucial for reducing wrinkles and improving skin firmness.
How do I use Night Repair Therapy?
Apply a pea-sized amount of Night Repair Therapy to cleansed skin in the evening, focusing on areas with visible signs of ageing.
Is Night Repair Therapy tested on animals?
No. Night Repair Therapy is cruelty-free and has not been tested on animals. Our commitment to ethical testing aligns with our goal to deliver results without compromising on quality or integrity.
How does Night Repair Therapy renew the skin?
The formula contains peptides and retinyl ester, which stimulate collagen and elastin production while promoting cellular turnover. Hyaluronic acid (in two different molecular weights) helps to maintain skin elasticity and moisture levels, providing a plump, youthful appearance.
What are the key ingredients in Night Repair Therapy?
Night Repair Therapy features a blend of peptides, retinyl ester, bilberry, hydrolysed tomato skin, two chains of hyaluronic acid. These ingredients work together to protect, renew, and restore the skin for optimal anti-ageing results.
Can I use Night Repair Therapy with other skincare products?
Absolutely. Night Repair Therapy easily integrates into your existing skincare routine or with our personalised routines: Chapters. Night Repair Therapy is best used after cleansing.
Is Night Repair Therapy suitable for sensitive skin?
Yes. Night Repair Therapy is designed to deliver powerful anti-ageing benefits without irritation, making it suitable for sensitive skin types. The unique formula combines active ingredients with soothing botanicals like bilberry and hydrolysed tomato skin to minimise risk of irritation.
How long does it take to see results with Night Repair Therapy?
You can expect to see visible improvements in your skin within 3 months of consistent use and continued improvement in the months following. Clinical studies show significant increases in collagen and elastin levels, which are key to reversing signs of ageing.
What makes Night Repair Therapy different from other anti-ageing creams?
Night Repair Therapy uses a unique three-step approach: protecting healthy cells, renewing damaged ones, and restoring the skin barrier. Unlike other retinoid products, it delivers results without irritation thanks to its carefully balanced blend of peptides, retinyl-ester, antioxidants, and advanced delivery mechanisms. It's been tested in double-blind, placebo-controlled clinical trials, ensuring its effectiveness.
I am sensitive to retinoids, will I be okay with Night Repair Therapy?
Our rigorous testing showed Night Repair Therapy to be well-tolerated for sensitive skin and retinoid sensitivity. However, everyone's skin is unique so if you're allergic to or have questions about specific ingredients, please reach out to our team who are happy to help.
Can I use Night Repair Therapy every night?
Yes, we encourage you to use it every night to see best results.
Can I use Night Repair Therapy while pregnant or breastfeeding?
Night Repair Therapy is not safe for breastfeeding due to the inclusion of retinoids in the formula.
Are all costmetic products tested on human skin?
No, many products aren't tested on human skin, which is why Night Repair Therapy is so unique.
How do I know it works?
By the rigorous testing we carry out. Night Repair Therapy has been held to the highest standard of scientific testing. Double-blind, placebo-controlled clinical studies in human skin.