Limited Edition Ultimate Skin Ageing Gift Set
Limited edition – available only while quantities last
This Christmas, discover the pinnacle of science-backed skincare, presented in our complimentary luxury gift box.
Exclusively for the festive season, this limited-edition set features The Ultimate Skin Longevity Duo: a complete AM and PM solution created by consultant dermatologists to protect your skin by day and repair it at night.
As with all Skin Diary formulations, the products within are clinically proven to defend against UV and environmental stressors, support cellular repair, and restore the skin's barrier function.
Available only while quantities last, this set is the definitive gift of skin health.
- Regular price
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£227.00 - Regular price
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£32.33 - Sale price
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£227.00
- Presented in a complimentary luxury Christmas gift box
- Strictly limited edition – available only while quantities last
- Complete AM / PM Routine in two products
- Protect against UV and environmental stressors
- Repair skin at a cellular level
- Restore the skin’s barrier function
- Suitable for sensitive skin
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Age Defence - Day Cream
Deeply nourishing all-day hydration with DNA repair enzymes, antioxidants and encapsulated sunscreen, restoring youthful skin function by helping prevent cellular senescence, inflammation and the breakdown of collagen and fibrillin.
- Lightweight, all-day hydration with a non-greasy finish
- Helps to repair UV-induced DNA damage
- Encapsulated broad-spectrum SPF50 | PA++++
- Dermatologically approved
Prevents collagen and fibrilin breakdown - Can be worn alone or under makeup
- Active protection against UV-induced molecular ageing and oxidative stress
- Scientifically proven to protect against UV-induced gene expression changes linked to cellular senescence, inflammaging and collagen breakdown
- Suitable for sensitive skin
Night Repair Therapy - Night Cream
Reverse signs of ageing with clinically proven skin repair—without irritation.
- 20x more effective than retinol
- Boosts collagen and elastin for firmer, youthful skin
- Repairs sun damage and restores skin barrier health
- Developed by world-leading dermatologists
- Gentle, irritation-free formula suitable for sensitive skin
Born from decades of pioneering research by Professor Chris Griffiths OBE and Dr. Tamara Griffiths. With research conducted in skin biology and regenerative medicine, this powerful formulation is clinically proven to increase collagen and elastin production, resulting in youthful-looking skin.
VIEW NIGHT REPAIR THERAPY
Clinically Proven Repair at Night
20x
More effective than retinols[1]2x
Increase in collagen[2]2x
Increase in fibrillin[2]Zero
IrritationClinically Proven
To reduce wrinkles [3][1] Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327-48. doi: 10.2147/ciia.2006.1.4.327. PMID: 18046911; PMCID: PMC2699641.
[2] Langton AK, McConnell JC, Cotterell LF, Halai P, Griffiths TW, Griffiths CEM, Watson REB. Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse (Night Repair Therapy), a novel over-the-counter anti-ageing product. J Eur Acad Dermatol Venereol. 2022 Jan;36(1):e43-e46. doi: 10.1111/jdv.17612. Epub 2021 Aug 30. PMID: 34416056.
[3] Independently proven on 29 people over 12 weeks p value 0.0004
Proven Daytime Protection
Prevents Cellular Senescence, Inflammation, and the Breakdown of Collagen and Fibrillin for Younger, Healthier Skin
We tested Age Defence with advanced gene expression testing in 3D human skin equivalents to measure its true impact on epigenetic ageing, cellular senescence and oxidative stress; three key biological pathways. This research was independently carried out by Professor Mark Birch-Machin, a Professor of molecular dermatology and widely recognised as a leading expert in UV-induced cellular damage to human skin and skin ageing.
The Results
Professor Birch Machin found:
Giving statistically significant protection against UV-induced P21 expression*
Complete reduction of PTGES expression to baseline levels following UV exposure*
Prevents the UV-induced spike in MMP1*
The Skin Diary Age Defence Moisturising Day Cream is proven for statistically significant protection against UV-induced epigenetic activity, supporting the role of our formula in modulating the skin’s biological ageing pathways.
The Skin Diary Age Defence Moisturising Day Cream is proven for statistically significant protection against UV-induced epigenetic activity, supporting the role of our formula in modulating the skin’s biological ageing pathways.
What is Cell Senescence
Cellular senescence is a key driver of ageing and one of the primary targets for skin regeneration. Senescent cells (or zombie cells) are retired; they stay alive but stop dividing and repairing themselves. These retired cells release inflammation, which can affect neighbouring cells.
They don’t function as they should, but they don’t die quietly, either. Instead, they hang around like a bad apple in a fruit down, slowly spreading dysfunction to the cells around them. This can result in a breakdown of collagen and elastin (fibrillin) production, inflammation, impaired skin cell renewal and age-related decline in regenerative capacity.
These ‘retired’ senescent cells build up and contribute to what we see as visible ageing. This molecular process starts a long time before the visible ageing appears, which is where prevention comes in. Minimising UV-induced cellular senescence in the skin is a great way to slow skin ageing.
What is Inflammageing?
Inflammageing is a slowly progressing, low-grade systemic inflammation that can lead to tissue damage and conditions associated with premature ageing. By focusing on protection from DNA repair enzymes, the goal is to reduce that inflammation and subsequent ageing factors.
Inflammageing is often considered a consequence of immunosenescence, which is the gradual decline of the immune system. A weakened immune system over time, limits the skin’s ability to repair itself and can lead to senescent cells, which increases overall inflammation. This creates an inflammatory environment, contributing to inflammageing.
Collagen & Fibrilins Role in Skin Ageing
Collagen is an abundant protein giving our skin its volume and strength. Fibrillin-rich microfibrils act as scaffolds for our skin’s elastic fibre formation, which is necessary for skin elasticity and resilience.
As we age, our collagen naturally degrades and our fibrillin can become damaged through various factors. They are not easily restored once the degradation has happened, but we do know that protection (sunscreen), retinoids (Night Repair Therapy) and restoration (DNA Repair Enzymes) work to restore both in photoaged skin.
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Night Repair TherapyNight Repair Therapy- Regular price
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£135.00 - Regular price
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- Sale price
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£135.00
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The Ultimate Skin Ageing DuoThe Ultimate Skin Ageing Duo- Regular price
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£227.00 - Regular price
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- Sale price
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£227.00
Quick view
